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| Rolex Paris Masters | ||
| Surface: Hard | Date: Oct. 31 - Nov. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yoshihito Nishioka | Win | 6-4, 6-4 |
| Third Round | Grigor Dimitrov | Win | 6-1, 6-3 |
| Quarterfinals | Holger Rune | Loss | 3-6, 6-6 Retired |
| Swiss Indoors Basel | ||
| Surface: Hard | Date: Oct. 24 - Oct. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jack Draper | Win | 3-6, 6-2, 7-5 |
| Second Round | Botic van de Zandschulp | Win | 6-4, 6-2 |
| Quarterfinals | Pablo Carreno Busta | Win | 6-3, 6-4 |
| Semifinals | Felix Auger-Aliassime | Loss | 3-6, 2-6 |
| The Astana Open | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | David Goffin | Loss | 5-7, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Sebastian Baez | Win | 7-5, 7-5, 2-0 Retired |
| Second Round | Federico Coria | Win | 6-2, 6-1, 7-5 |
| Third Round | Jenson Brooksby | Win | 6-3, 6-3, 6-3 |
| Fourth Round | Marin Cilic | Win | 6-4, 3-6, 6-4, 4-6, 6-3 |
| Quarterfinals | Jannik Sinner | Win | 6-3, 6-7 (7-9), 6-7 (0-7), 7-5, 6-3 |
| Semifinals | Frances Tiafoe | Win | 6-7 (6-8), 6-3, 6-1, 6-7(5-7), 6-3 |
| Final | Casper Ruud | Win | 6-4, 2-6, 7-6 (7-1), 6-3 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | |
| Third Round | Marin Cilic | Win | |
| Quarterfinals | Cameron Norrie | Loss |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tommy Paul | Loss |
| Plava Laguna Croatia Open Umag | ||
| Surface: Clay | Date: Jul. 25 - Jul. 31 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Norbert Gombos | Win | |
| Quarterfinals | Facundo Bagnis | Win | |
| Semifinals | Giulio Zeppieri | Win | |
| Final | Jannik Sinner | Loss |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 17 - Jul. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Nicola Kuhn | Win | |
| Second Round | Filip Krajinovic | Win | |
| Quarterfinals | Karen Khachanov | Win | |
| Semifinals | Alex Molcan | Win | |
| Final | Lorenzo Musetti | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | |
| Second Round | Tallon Griekspoor | Win | |
| Third Round | Oscar Otte | Win | |
| Fourth Round | Jannik Sinner | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Juan Ignacio Londero | Win | |
| Second Round | Albert Ramos-Vinolas | Win | |
| Third Round | Sebastian Korda | Win | |
| Fourth Round | Karen Khachanov | Win | |
| Quarterfinals | Alexander Zverev | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nikoloz Basilashvili | Win | |
| Third Round | Cameron Norrie | Win | |
| Quarterfinals | Rafael Nadal | Win | |
| Semifinals | Novak Djokovic | Win | |
| Final | Alexander Zverev | Win |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Soon Woo Kwon | Win | |
| Third Round | Jaume Munar | Win | |
| Quarterfinals | Stefanos Tsitsipas | Win | |
| Semifinals | Alex De Minaur | Win | |
| Final | Pablo Carreno Busta | Win |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Korda | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | |
| Third Round | Marin Cilic | Win | |
| Fourth Round | Stefanos Tsitsipas | Win | |
| Quarterfinals | Miomir Kecmanovic | Win | |
| Semifinals | Hubert Hurkacz | Win | |
| Final | Casper Ruud | Win |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | |
| Third Round | Roberto Bautista Agut | Win | |
| Fourth Round | Gael Monfils | Win | |
| Quarterfinals | Cameron Norrie | Win | |
| Semifinals | Rafael Nadal | Loss |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 14 - Feb. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jaume Munar | Win | |
| Second Round | Federico Delbonis | Win | |
| Quarterfinals | Matteo Berrettini | Win | |
| Semifinals | Fabio Fognini | Win | |
| Final | Diego Schwartzman | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Tabilo | Win | |
| Second Round | Dusan Lajovic | Win | |
| Third Round | Matteo Berrettini | Loss |
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