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| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | 4-6, 7-5, 4-6, 7-6(7-3), 6-4 |
| Second Round | Tallon Griekspoor | Win | 6-4, 7-6 (7-0), 6-3 |
| Third Round | Oscar Otte | Win | 6-3, 6-1, 6-2 |
| Fourth Round | Jannik Sinner | Loss | 1-6, 4-6, 7-6 (10-8), 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Juan Ignacio Londero | Win | 6-4, 6-2, 6-0 |
| Second Round | Albert Ramos-Vinolas | Win | 6-1, 6-7 (7-9), 5-7, 7-6(7-2), 6-4 |
| Third Round | Sebastian Korda | Win | 6-4, 6-4, 6-2 |
| Fourth Round | Karen Khachanov | Win | 6-1, 6-4, 6-4 |
| Quarterfinals | Alexander Zverev | Loss | 4-6, 4-6, 6-4, 6-7 (7-9) |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nikoloz Basilashvili | Win | 6-3, 7-5 |
| Third Round | Cameron Norrie | Win | 6-4, 6-7 (4-7), 6-3 |
| Quarterfinals | Rafael Nadal | Win | 6-2, 1-6, 6-3 |
| Semifinals | Novak Djokovic | Win | 6-7 (5-7), 7-5, 7-6 (7-5) |
| Final | Alexander Zverev | Win | 6-3, 6-1 |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Soon Woo Kwon | Win | 6-1, 2-6, 6-2 |
| Third Round | Jaume Munar | Win | 6-3, 6-3 |
| Quarterfinals | Stefanos Tsitsipas | Win | 6-4, 5-7, 6-2 |
| Semifinals | Alex De Minaur | Win | 6-7 (4-7), 7-6 (7-4), 6-4 |
| Final | Pablo Carreno Busta | Win | 6-3, 6-2 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Korda | Loss | 6-7 (2-7), 7-6 (7-5), 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | 6-3, 6-2 |
| Third Round | Marin Cilic | Win | 6-4, 6-4 |
| Fourth Round | Stefanos Tsitsipas | Win | 7-5, 6-3 |
| Quarterfinals | Miomir Kecmanovic | Win | 6-7 (5-7), 6-3, 7-6 (7-5) |
| Semifinals | Hubert Hurkacz | Win | 7-6 (7-5), 7-6 (7-2) |
| Final | Casper Ruud | Win | 7-5, 6-4 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | 6-3, 6-3 |
| Third Round | Roberto Bautista Agut | Win | 6-2, 6-0 |
| Fourth Round | Gael Monfils | Win | 7-5, 6-1 |
| Quarterfinals | Cameron Norrie | Win | 6-4, 6-3 |
| Semifinals | Rafael Nadal | Loss | 4-6, 6-4, 3-6 |
| Rio Open presented by Claro HDTV | ||
| Surface: Clay | Date: Feb. 14 - Feb. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jaume Munar | Win | 2-6, 6-2, 6-1 |
| Second Round | Federico Delbonis | Win | 6-4, 7-6 (7-1) |
| Quarterfinals | Matteo Berrettini | Win | 6-2, 2-6, 6-2 |
| Semifinals | Fabio Fognini | Win | 6-2, 7-5 |
| Final | Diego Schwartzman | Win | 6-4, 6-2 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Tabilo | Win | 6-2, 6-2, 6-3 |
| Second Round | Dusan Lajovic | Win | 6-2, 6-1, 7-5 |
| Third Round | Matteo Berrettini | Loss | 2-6, 6-7 (3-7), 6-4, 6-2, 6-7 (5-10) |
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