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| Rolex Shanghai Masters | ||
| Surface: Hard | Date: Oct. 7 - Oct. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniil Medvedev | Win | 6-4, 4-6, 6-4 |
| Third Round | Roberto Bautista Agut | Win | 6-3, 2-6, 6-4 |
| Quarterfinals | Kei Nishikori | Win | 6-4, 7-6 (7-4) |
| Semifinals | Borna Coric | Loss | 4-6, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Yoshihito Nishioka | Win | 6-2, 6-2, 6-4 |
| Second Round | Benoit Paire | Win | 7-5, 6-4, 6-4 |
| Third Round | Nick Kyrgios | Win | 6-4, 6-1, 7-5 |
| Fourth Round | John Millman | Loss | 6-3, 5-7, 6-7 (7-9), 6-7 (3-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Peter Gojowczyk | Win | 6-4, 6-4 |
| Third Round | Leonardo Mayer | Win | 6-1, 7-6 (8-6) |
| Quarterfinals | Stan Wawrinka | Win | 6-7 (2-7), 7-6 (8-6), 6-2 |
| Semifinals | David Goffin | Win | 7-6 (7-3), 1-1 Retired |
| Final | Novak Djokovic | Loss | 4-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Dusan Lajovic | Win | 6-1, 6-3, 6-4 |
| Second Round | Lukas Lacko | Win | 6-4, 6-4, 6-1 |
| Third Round | Jan-Lennard Struff | Win | 6-3, 7-5, 6-2 |
| Fourth Round | Adrian Mannarino | Win | 6-0, 7-5, 6-4 |
| Quarterfinals | Kevin Anderson | Loss | 6-2, 7-6 (7-5), 5-7, 4-6, 11-13 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Aljaz Bedene | Win | 6-3, 6-4 |
| Second Round | Benoit Paire | Win | 6-3, 3-6, 7-6 (9-7) |
| Quarterfinals | Matthew Ebden | Win | 7-6 (7-2), 7-5 |
| Semifinals | Denis Kudla | Win | 7-6 (7-1), 7-5 |
| Final | Borna Coric | Loss | 6-7 (6-8), 6-3, 2-6 |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 11 - Jun. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mischa Zverev | Win | 3-6, 6-4, 6-2 |
| Quarterfinals | Guido Pella | Win | 6-4, 6-4 |
| Semifinals | Nick Kyrgios | Win | 6-7 (2-7), 6-2, 7-6 (7-5) |
| Final | Milos Raonic | Win | 6-4, 7-6 (7-3) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thanasi Kokkinakis | Loss | 6-3, 3-6, 6-7 (4-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Federico Delbonis | Win | 6-3, 7-6 (8-6) |
| Third Round | Filip Krajinovic | Win | 6-2, 6-1 |
| Fourth Round | Jeremy Chardy | Win | 7-5, 6-4 |
| Quarterfinals | Hyeon Chung | Win | 7-5, 6-1 |
| Semifinals | Borna Coric | Win | 5-7, 6-4, 6-4 |
| Final | Juan Martin Del Potro | Loss | 4-6, 7-6 (10-8), 6-7 (2-7) |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ruben Bemelmans | Win | 6-1, 6-2 |
| Second Round | Philipp Kohlschreiber | Win | 7-6 (10-8), 7-5 |
| Quarterfinals | Robin Haase | Win | 4-6, 6-1, 6-1 |
| Semifinals | Andreas Seppi | Win | 6-3, 7-6 (7-3) |
| Final | Grigor Dimitrov | Win | 6-2, 6-2 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Aljaz Bedene | Win | 6-3, 6-4, 6-3 |
| Second Round | Jan-Lennard Struff | Win | 6-4, 6-4, 7-6 (7-4) |
| Third Round | Richard Gasquet | Win | 6-2, 7-5, 6-4 |
| Fourth Round | Marton Fucsovics | Win | 6-4, 7-6 (7-3), 6-2 |
| Quarterfinals | Tomas Berdych | Win | 7-6 (7-1), 6-3, 6-4 |
| Semifinals | Hyeon Chung | Win | 6-1, 5-2 Retired |
| Final | Marin Cilic | Win | 6-2, 6-7 (5-7), 6-3, 3-6, 6-1 |
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