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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Fabio Fognini | Loss | 4-6, 4-6, 3-6 |
| Open Parc Auvergne-Rhone-Alpes Lyon | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pablo Llamas Ruiz | Win | 7-5, 6-2 |
| Quarterfinals | Arthur Fils | Loss | Retired |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexei Popyrin | Loss | 4-6, 6-4, 5-7 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Loss | 2-6, 6-3, 6-7 (5-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thiago Monteiro | Win | 7-6 (7-5), 7-6 (10-8) |
| Third Round | Francisco Cerundolo | Loss | 2-6, 5-7 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Martinez | Win | 7-6 (7-5), 6-4 |
| Third Round | Francisco Cerundolo | Win | 7-5, 6-4 |
| Fourth Round | Tommy Paul | Win | 3-6, 6-3, 7-6 (8-6) |
| Quarterfinals | Carlos Alcaraz | Loss | 4-6, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Maxime Cressy | Win | 7-6 (7-4), 3-6, 6-3 |
| Second Round | Lorenzo Sonego | Loss | 6-7 (4-7), 4-6 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jason Kubler | Win | 4-6, 6-1, 6-4 |
| Quarterfinals | Alejandro Davidovich Fokina | Win | 6-4, 7-6 (7-5) |
| Semifinals | Daniil Medvedev | Loss | 4-6, 6-7 (7-9) |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Sonego | Win | 6-2, 6-3 |
| Second Round | Gregoire Barrere | Win | 6-4, 6-3 |
| Quarterfinals | Daniil Medvedev | Loss | 2-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Vasek Pospisil | Win | |
| Second Round | Alex Molcan | Win | |
| Third Round | Francisco Cerundolo | Win | |
| Fourth Round | Jiri Lehecka | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alexei Popyrin | Loss |
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