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| AGEL Open 2022 | ||
| Surface: Hard | Date: Oct. 3 - Oct. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Kvitova | Loss | 6-7 (4-7), 4-6 |
| Toray Pan Pacific Open | ||
| Surface: Hard | Date: Sep. 19 - Sep. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Qinwen Zheng | Loss | 3-6, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | 3-6, 7-6 (7-4), 6-3 |
| Second Round | Petra Martic | Loss | 7-6 (7-5), 1-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Loss |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elizabeth Mandlik | Win | |
| Quarterfinals | Coco Gauff | Win | |
| Semifinals | Daria Kasatkina | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Louisa Chirico | Win | |
| Second Round | Irina Bara | Win | |
| Third Round | Petra Kvitova | Win | |
| Fourth Round | Simona Halep | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jodie Burrage | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Fiona Ferro | Win | |
| Second Round | Kaja Juvan | Win | |
| Third Round | Veronika Kudermetova | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Win | |
| Third Round | Daria Kasatkina | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Win | |
| Second Round | Simona Halep | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena Rybakina | Win | |
| Quarterfinals | Ons Jabeur | Win | |
| Semifinals | Aryna Sabalenka | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 4 - Apr. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Bondar | Win | |
| Third Round | Claire Liu | Win | |
| Quarterfinals | Belinda Bencic | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marie Bouzkova | Win | |
| Third Round | Yulia Putintseva | Win | |
| Fourth Round | Linda Fruhvirtova | Win | |
| Quarterfinals | Jessica Pegula | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tereza Martincova | Win | |
| Third Round | Sara Sorribes Tormo | Win | |
| Fourth Round | Leylah Fernandez | Win | |
| Quarterfinals | Veronika Kudermetova | Win | |
| Semifinals | Maria Sakkari | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Clara Tauson | Win | |
| Third Round | Cori Gauff | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Elena-Gabriela Ruse | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | |
| Second Round | Martina Trevisan | Win | |
| Third Round | Marta Kostyuk | Win | |
| Fourth Round | Madison Keys | Loss |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jelena Ostapenko | Win | |
| Second Round | Ajla Tomljanovic | Win | |
| Quarterfinals | Belinda Bencic | Win | |
| Semifinals | Daria Kasatkina | Win | |
| Final | Barbora Krejcikova | Win |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 3 - Jan. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Victoria Azarenka | Loss |
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