NFL Leaders |
Rushing Touchdowns
| Rank | Name | Team | G | Rushes | Rush Yds | Yd/G | Avg | TD |
| 1 | J. Williams | Det | 17 | 262 | 1066 | 62.7 | 4.07 | 17 |
| 2t | A. Ekeler | LAC | 17 | 204 | 915 | 53.8 | 4.49 | 13 |
| 2t | D. Henry | Ten | 16 | 349 | 1538 | 96.1 | 4.41 | 13 |
| 2t | J. Hurts | Phi | 15 | 165 | 760 | 50.7 | 4.61 | 13 |
| 5t | N. Chubb | Cle | 17 | 302 | 1525 | 89.7 | 5.05 | 12 |
| 5t | E. Elliott | Dal | 15 | 231 | 876 | 58.4 | 3.79 | 12 |
| 5t | J. Jacobs | LV | 17 | 340 | 1653 | 97.2 | 4.86 | 12 |
| 8 | M. Sanders | Phi | 17 | 259 | 1269 | 74.6 | 4.90 | 11 |
| 9 | S. Barkley | NYG | 16 | 295 | 1312 | 82.0 | 4.45 | 10 |
| 10t | T. Pollard | Dal | 16 | 193 | 1007 | 62.9 | 5.22 | 9 |
| 10t | K. Walker III | Sea | 15 | 228 | 1050 | 70.0 | 4.61 | 9 |
| 12t | D. Cook | Min | 17 | 264 | 1173 | 69.0 | 4.44 | 8 |
| 12t | J. Fields | Chi | 15 | 160 | 1143 | 76.2 | 7.14 | 8 |
| 12t | C. McCaffrey | SF | 17 | 244 | 1139 | 67.0 | 4.67 | 8 |
| 12t | C. Patterson | Atl | 13 | 144 | 695 | 53.5 | 4.83 | 8 |
| 16t | C. Akers | LAR | 15 | 188 | 786 | 52.4 | 4.18 | 7 |
| 16t | J. Allen | Buf | 16 | 124 | 762 | 47.6 | 6.15 | 7 |
| 16t | J. Conner | Ari | 13 | 183 | 782 | 60.2 | 4.27 | 7 |
| 16t | A. Dillon | GB | 17 | 186 | 770 | 45.3 | 4.14 | 7 |
| 16t | N. Harris | Pit | 17 | 272 | 1034 | 60.8 | 3.80 | 7 |
| 16t | T. Hill | NO | 16 | 96 | 575 | 35.9 | 5.99 | 7 |
| 16t | D. Jones | NYG | 16 | 120 | 708 | 44.3 | 5.90 | 7 |
| 16t | J. Mixon | Cin | 14 | 210 | 814 | 58.1 | 3.88 | 7 |
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